Electrophysiological Assessment of Diabetic Neuropathy Improvements by using Insulin and Thiamine

Electrophysiological Assessment of Diabetic Neuropathy Improvements by using Insulin and Thiamine

I. W. Muflih*, A.M. Abdul-Kareem** G.A. Al-Sharify***

*Faculty of Pharmacy, An-Najah National University, Nablus, Palestine. **Sadam College of medicine, Baghdad, ***Al-Yarmouk Hospital, Baghdad.

Received : 29-05-2001 , Accepted : 07-05-2002

Language: English

Abstract

Two groups of (type II) non-insulin dependent diabetes mellitus (NIDDM) patients were assisted electophysiologly for the neuropathy of their peripheral nerves and compared with the control group. The assessments aimed to evaluate the levels of improvements that may occur in the functions of seven peripheral nerves by using insulin (group 1) and thiamine (group 2) as a treatment modalities. The obtained results of the first visit of the patients of both groups showed significant changes in the recordings of the examined parameters (latency, conductive velocity and amplitude) of the peripheral nerves compared to the recordings of the control group. The nerves conduction study (NCS) of the newly diagnosed type II diabetic patients who were shifted to insulin gave statistical significant variable improvements at the 12 month of re-examination and in the three parameters of all the tested nerves at the 18 month of re-examination, compared to the first visit of the patients. The effectiveness of thiamine (vit. B1) on the type II diabetic patients seems to be used for the first time, in the present study. The obtained results showed improvement in the tested parameters of three nerves only, namely the median and ulnar sensory nerves in addition to the sural nerves compared to the first visit records of the patients. Key words: Insulin and Thiamine Effectiveness on Neuropathy of type II diabetic patients.

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